1092 Mechanism of action of Oligofructansfrom Ophiopogon japonicus to treat atopic dermatitis

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Management of difficult-to-treat atopic dermatitis.

Atopic dermatitis is a complex disorder caused by the interplay between multiple genetic and environmental factors. Particularly in patients with severe disease, the effect is not just an itchy rash but also the secondary effects on the psychological well-being of the patient and their carers, particularly disturbed sleep. The aim of this review is to provide health care professionals with a ho...

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Enhancement of Growth Performances of Ophiopogon japonicus Ornamental Foliage Plant

Ophiopogon japonicus is a perennial, ornamental foliage plant, whichbelongs to the family Liliaceae. It has a high demand in the local andinternational export market due to the presence of glossy white-green stripped lanceolate leaves. Improved leaves and plants of O. japonicus will be more popular in the floriculture industry. Hence, objective was to investigate the growth responses of O. japo...

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Pathogenesis of Atopic Dermatitis: Current Paradigm

Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such a...

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Homoisoflavonoids and the Antioxidant Activity of Ophiopogon japonicus Root

The root of Ophiopogon japonicus has been used as a traditional Chinese medicine and also a functional food ingredient for a long time in China. In the present study, 17 different homoisoflavonoid compounds were identified in the root extract of O. japonicus by HPLC–DAD and LCMS/MS analyses. The antioxidant activity of the of chloroform/methanol (1:1, v/v), methanol and 70% ethanol extracts, an...

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Antimicrobial activities of endophytic fungi isolated from Ophiopogon japonicus (Liliaceae)

BACKGROUND Drug resistance in bacteria has become a global concern and the search for new antibacterial agents is urgent and ongoing. Endophytes provide an abundant reservoir of bioactive metabolites for medicinal exploitation, and an increasing number of novel compounds are being isolated from endophytic fungi. Ophiopogon japonicus, containing compounds with antibacterial activity, is a tradit...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2018

ISSN: 0022-202X

DOI: 10.1016/j.jid.2018.03.1105